Data Validation through Tissue Analysis
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by: Stephen Jones
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Word Count: 202
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The existing body of literature using Western blot analysis
has been primarily defined with data from tumor, immortal, and primary cells
growing in vitro. Collectively, results obtained over decades have been
integral to the dogma that up- and down-regulation of proteins can be leveraged
as Biomarkers of normal development, homeostasis, and disease. However,
in contrast to tissues which are composed of multiple cell types, cell lines
growing in culture which theoretically consist of clonal populations. Thus,
validation or modification of western blot parameters collectively established
from decades of cell line data in tissue lysates is key for Biomarker
discovery. Related
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